Correlation analysis of four KRTAP gene polymorphisms and cashmere fiber diameters in two cashmere goat breeds

Fiber diameter, a quantitative trait, is controlled by minor effect polygenes. Keratin-associated proteins (KRTAPs) are an important part of hair, and their rich polymorphisms facilitate the mining cashmere trait molecular markers. In this study, Jiangnan Tibetan goats were taken as research object; multiplex PCR exome sequencing technology used to identify exon regional KRTAP15-1, KRTAP13.1, KRTAP27-1, KRTAP24-1. The effects mutation sites on fiber diameter analyzed least square method. results showed that there 28 in four KRTAP genes goat populations. Among them, KRTAP24-1 gene found be significantly related goats. exploration markers study will help improve down, while identification provide original data for utilization protection germplasm resources